Open AccessEnzyme-Functionalized Mesoporous Silica Nanoparticles to Target Staphylococcus aureus and Disperse Biofilms
Author(s) -
Henry B. Devlin,
Stephanie Fulaz,
Dishon Hiebner,
James P. O’Gara,
Eoin Casey
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s293190
Subject(s) - biofilm , staphylococcus aureus , microbiology and biotechnology , mesoporous silica , antimicrobial , nanocarriers , chemistry , bacteria , materials science , drug delivery , biology , nanotechnology , biochemistry , mesoporous material , genetics , catalysis
Staphylococcus aureus biofilms pose a unique challenge in healthcare due to their tolerance to a wide range of antimicrobial agents. The high cost and lengthy timeline to develop novel therapeutic agents have pushed researchers to investigate the use of nanomaterials to deliver antibiofilm agents and target biofilm infections more efficiently. Previous studies have concentrated on improving the efficacy of antibiotics by deploying nanoparticles as nanocarriers. However, the dispersal of the extracellular polymeric substance (EPS) matrix in biofilm-associated infections is also critical to the development of novel nanoparticle-based therapies.