Open AccessMeasuring Nanoparticle Penetration Through Bio-Mimetic Gels
Author(s) -
Scott McCormick,
Namid Stillman,
Matthew J. Hockley,
Adam W. Perriman,
Sabine Hauert
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s292131
Subject(s) - nanocarriers , penetration (warfare) , nanotechnology , materials science , nanoparticle , nanomedicine , self healing hydrogels , biomedical engineering , biophysics , medicine , operations research , polymer chemistry , engineering , biology
In cancer nanomedicine, drugs are transported by nanocarriers through a biological system to produce a therapeutic effect. The efficacy of the treatment is affected by the ability of the nanocarriers to overcome biological transport barriers to reach their target. In this work, we focus on the process of nanocarrier penetration through tumour tissue after extravasation. Visualising the dynamics of nanocarriers in tissue is difficult in vivo, and in vitro assays often do not capture the spatial and physical constraints relevant to model tissue penetration.