Open AccessEffect of Gold Nanoparticle Radiosensitization on Plasmid DNA Damage Induced by High-Dose-Rate Brachytherapy
Author(s) -
Katsunori Yogo,
Masaki Misawa,
Morihito Shimizu,
Hidetoshi Shimizu,
Tomoki Kitagawa,
Ryoichi Hirayama,
Hiromichi Ishiyama,
Takako Furukawa,
Hiroshi Yasuda
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s292105
Subject(s) - colloidal gold , dna damage , agarose gel electrophoresis , dna , reactive oxygen species , agarose , biophysics , brachytherapy , plasmid , irradiation , microbiology and biotechnology , gel electrophoresis , chemistry , materials science , nanoparticle , nanotechnology , biology , biochemistry , radiation therapy , medicine , physics , nuclear physics
Gold nanoparticles (AuNPs) are candidate radiosensitizers for medium-energy photon treatment, such as γ-ray radiation in high-dose-rate (HDR) brachytherapy. However, high AuNP concentrations are required for sufficient dose enhancement for clinical applications. Here, we investigated the effect of positively (+) charged AuNP radiosensitization of plasmid DNA damage induced by 192Ir γ-rays, and compared it with that of negatively (-) charged AuNPs.