Open AccessProtein Nanoparticle-Related Osmotic Pressure Modifies Nonselective Permeability of the Blood–Brain Barrier by Increasing Membrane Fluidity
Author(s) -
Chen Li,
Linlin Chen,
YuanYuan Wang,
Tingting Wang,
Dong Di,
Hao Zhang,
Huanhuan Zhao,
Xu Shen,
J. Guo
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s291286
Subject(s) - occludin , biophysics , intracellular , osmotic pressure , tight junction , chemistry , osmotic shock , microbiology and biotechnology , biochemistry , biology , gene
Intracellular tension plays a crucial role in the destruction of the blood-brain barrier (BBB) in response to lesion stimuli. Tight junction structure could be primarily affected by tension activity. In this study, we aimed to determine the effects of extracellular BBB damage on intracellular tension activity, and elucidate the mechanism underlying the effects of intracellular protein nanoparticle-related osmotic pressure on BBB permeability.