Open AccessThe Stability of Dentin Surface Biobarrier Consisting of Mesoporous Delivery System on Dentinal Tubule Occlusion and Streptococcus Mutans Biofilm Inhibition
Author(s) -
Jianming Yu,
Luyao Yi,
Rui Guo,
Jingyi Guo,
Hongye Yang,
Cui Huang
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s290254
Subject(s) - dentin , dentinal tubule , streptococcus mutans , dentin hypersensitivity , biofilm , amorphous calcium phosphate , chemistry , mesoporous material , tooth remineralization , biophysics , tooth surface , mesoporous silica , dentistry , enamel paint , materials science , calcium , biochemistry , remineralisation , medicine , bacteria , biology , genetics , organic chemistry , catalysis
The dentin exposure always leads to dentin hypersensitivity and/or caries. Given the dentin's tubular structure and low mineralization degree, reestablishing an effective biobarrier to stably protect dentin remains significantly challenging. This study reports a versatile dentin surface biobarrier consisting of a mesoporous silica-based epigallocatechin-3-gallate (EGCG)/nanohydroxyapatite delivery system and evaluates its stability on the dentinal tubule occlusion and the Streptococcus mutans ( S. mutans ) biofilm inhibition.