Open AccessMetabolic Conversion and Removal of Manganese Ferrite Nanoparticles in RAW264.7 Cells and Induced Alteration of Metal Transporter Gene Expression
Author(s) -
Liang Zhang,
Shilin Xiao,
Xun Kang,
Tao Sun,
Chunyu Zhou,
Zhongsheng Xu,
Mengmeng Du,
Ya Yu Zhang,
Guangxian Wang,
Yun Liu,
Dong Dong Zhang,
Mingfu Gong
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s289707
Subject(s) - cytotoxicity , chemistry , efflux , nuclear chemistry , dmt1 , nanoparticle , manganese , transfection , microbiology and biotechnology , gene expression , biophysics , transporter , gene , metal , biochemistry , biology , materials science , in vitro , nanotechnology , organic chemistry
Manganese Ferrite Nanoparticles (Mn-IONPs) are widely used in biomedical field and their cytotoxicity has been initially explored, but the mechanism remains obscure. The nano-bio interactions are believed to be crucial for cytotoxicity mechanism, while little data have been acquired.