Open AccessPreparation and Evaluation of Lipid Emulsion Containing 13 Vitamins for Injection Without Anaphylactoid Reactions
Author(s) -
Min-quan Hui,
Yan-ni Mi,
Yan Ma,
Tao Chen,
Ricardo Cao
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s289596
Subject(s) - lecithin , histamine , chemistry , emulsion , chromatography , multivitamin , dispersity , particle size , pharmacology , vitamin , medicine , biochemistry , organic chemistry
Multivitamins containing Tween 80 can cause anaphylactoid reactions. The objective of this study was to develop a new lipid emulsion containing 13 fat- and water-soluble vitamins for injection (13V-LE) that were simultaneously dissolved in one bottle and to evaluate the stability of and anaphylactoid reactions to 13V-LE.