Open AccessA Smart Multifunctional Nanoparticle for Enhanced Near-Infrared Image-Guided Photothermal Therapy Against Gastric Cancer
Author(s) -
Jun Shao,
Rongpu Liang,
Dongbing Ding,
Xiaoming Zheng,
Xudong Zhu,
Shengxue Hu,
Wei H,
Bo Wei
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s289310
Subject(s) - photothermal therapy , indocyanine green , in vivo , cancer , cancer research , materials science , cancer cell , drug delivery , medicine , nanotechnology , pathology , biology , microbiology and biotechnology
Surgery is considered to be a potentially curative approach for gastric cancer. However, most cases are diagnosed at a very advanced stage for the lack of typical symptoms in the initial stage, which makes it difficult to completely surgical resect of tumors. Early diagnosis and precise personalized intervention are urgent issues to be solved for improving the prognosis of gastric cancer. Herein, we developed an RGD-modified ROS-responsive multifunctional nanosystem for near-infrared (NIR) imaging and photothermal therapy (PTT) against gastric cancer.