Open Access<p>Tadalafil-Loaded Limonene-Based Orodispersible Tablets: Formulation, in vitro Characterization and in vivo Appraisal of Gastroprotective Activity</p>
Author(s) -
Mohammed M. Mehanna,
Amina Tarek Mneimneh,
Souraya Domiati,
Ahmed N. Allam
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s288552
Subject(s) - friability , tadalafil , ulcer index , zeta potential , pharmacology , limonene , medicine , materials science , chemistry , chromatography , pharmacokinetics , surgery , nanotechnology , essential oil , stomach , nanoparticle , gastric mucosa , first pass effect , erectile dysfunction
Gastric ulcer is a prevalent disease with various etiologies, including non-steroidal anti-inflammatory drugs and alcohol consumption. This study aimed to explore the dual gastric protection effect of tadalafil and limonene as a self-nanoemulsifying system (SNES)-based orodispersible tablets.