Open Access<p>Low-Frequency versus High-Frequency Ultrasound-Mediated Transdermal Delivery of Agomelatine-Loaded Invasomes: Development, Optimization and in-vivo Pharmacokinetic Assessment</p>
Author(s) -
Mohammad Tawfik,
Mina Ibrahim Tadros,
M. I. Mohamed,
Sara Nageeb El-Helaly
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s283911
Subject(s) - transdermal , bioavailability , citral , pharmacokinetics , materials science , first pass effect , in vivo , pharmacology , limonene , chemistry , biomedical engineering , chromatography , medicine , essential oil , biology , microbiology and biotechnology
Agomelatine (AGM) is the first melatonergic antidepressant. It suffers from low oral bioavailability (<5%) due to extensive hepatic metabolism. The current work aimed to develop an alternative AGM-loaded invasomes to enhance transdermal drug bioavailability.