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Agomelatine (AGM) is the first melatonergic antidepressant. It suffers from low oral bioavailability (&lt;5%) due to extensive hepatic metabolism. The current work aimed to develop an alternative AGM-loaded invasomes to enhance transdermal drug bioavailability.

international journal of nanomedicine

&lt;p&gt;Low-Frequency versus High-Frequency Ultrasound-Mediated Transdermal Delivery of Agomelatine-Loaded Invasomes: Development, Optimization and in-vivo Pharmacokinetic Assessment&lt;/p&gt;