Open Access<p>Effect of Starvation in Reversing Cancer Chemoresistance Based on Drug-Resistance Detection by Dextran Nanoparticles</p>
Author(s) -
Chenglong Wang,
Xuzhu Gao,
Fanchen Wang,
Wencai Guan,
Hongjing Dou,
Guoxiong Xu
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s283430
Subject(s) - drug resistance , cancer cell , multiple drug resistance , cancer research , cancer , starvation , protease , p glycoprotein , chemotherapy , cisplatin , cell , efflux , drug , cell culture , pharmacology , chemistry , biology , medicine , biochemistry , enzyme , microbiology and biotechnology , genetics
Chemoresistance leads to chemotherapy failure in patients with cancer. Multidrug resistance (MDR) in cancer is mainly caused by the high expression of P-glycoprotein encoded by the MDR1 gene, which is an ATP-dependent protease. Keeping the stronger invasion and migration abilities of chemoresistant cells in cancer also requires more ATP consumption. Herein, we aimed to reverse resistance by reducing the glucose supply in the cellular environment.