Open AccessPterostilbene Nanoparticles Downregulate Hypoxia-Inducible Factors in Hepatoma Cells Under Hypoxic Conditions
Author(s) -
Wen-Sheng Tzeng,
Weilin Teng,
Pao-Hsien Huang,
Tzu-Ching Lin,
FengLin Yen,
YowLing Shiue
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s282172
Subject(s) - hypoxia (environmental) , pterostilbene , apoptosis , nanoparticle , chemistry , solubility , tumor hypoxia , cytotoxicity , hepatocellular carcinoma , viability assay , particle size , pharmacology , cancer research , materials science , biophysics , biochemistry , oxygen , medicine , in vitro , nanotechnology , biology , surgery , organic chemistry , resveratrol , radiation therapy
Transcatheter arterial chemoembolization (TACE) is a common clinical treatment for hepatocellular carcinoma (HCC). However, hypoxia induction after treatment might trigger tumor invasiveness and metastasis. Although pterostilbene (PTS) has antitumor effects, its chemoprevention in HepG2 cells under hypoxia has not been investigated yet. In addition, the poor water solubility of raw PTS limits its clinical application. Here, we prepared nanoparticles of PTS (PSN) and compared their antihepatoma activities with those of raw PTS in HepG2 under hypoxic conditions.