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<p>New Oral Coaxial Nanofibers for Gadodiamide-Prospective Intestinal Magnetic Resonance Imaging and Theranostic</p>
Author(s) -
Alaa Yaser Darwesh,
Marwa S. El-Dahhan,
Mahasen Mohamed Meshali
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s281158
Subject(s) - thermogravimetric analysis , gadodiamide , materials science , nanofiber , electrospinning , biomedical engineering , chemistry , nanotechnology , polymer , medicine , organic chemistry , composite material , gadolinium , metallurgy
Gadodiamide (GDD) is a widely used magnetic resonance imaging (MRI) contrast agent. It is available only as intravenous injection. Unfortunately, it exhibits a high renal toxicity. In this respect, the author investigated the possibility of developing nanofibers (NFs, one-dimensional (1D) nanostructures) of GDD that would be promising for oral administration in intestinal imaging. NFs are prepared by electrospinning technique in which a strong electrostatic field is applied on a polymer solution.

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