Open AccessTherapeutic Effect of Calcipotriol Pickering Nanoemulsions Prepared by Exopolysaccharides Produced by Bacillus halotolerans FYS Strain on Psoriasis
Author(s) -
Yuzhen Wang,
Hong Li,
Fakun Dong,
Yan Fang,
Min Cheng,
Wanzhong Li,
Qi Cui,
Tianzi Song,
Aoying Liu,
Bo Song
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s278247
Subject(s) - gel permeation chromatography , chemistry , polysaccharide , glucuronic acid , rhamnose , pickering emulsion , materials science , nanoparticle , biochemistry , organic chemistry , nanotechnology , polymer
Many exopolysaccharides (EPS) have significant emulsifying activity. Some EPS produced by the marine bacterial strain FYS have stronger emulsifying activity in the form of nanoparticles, suggesting that they could potentially form Pickering emulsions. We prepared novel EPS/CT Pickering nanoemulsions (ECPN) with EPS as emulsifiers and assessed their ability to ameliorate the poor permeability of calcipotriol (CT) in skin affected by psoriasis vulgaris.