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Reducing toxicity, immunogenicity, and costs of small interfering RNAs (siRNA) carrier materials are key goals for RNA interference (RNAi) technology transition from bench to bed. Recently, calcium ions (Ca 2+ ) have garnered attention as a novel, alternative material for delivering siRNA to cells. However, the tolerance for Ca 2+ concentration varies in different cell types, which has limited its applications in vivo. Bovine serum albumin (BSA) can bind to Ca 2+ hrough chelation. Moreover, BSA is a favorable coating material for nanoparticles owing to its excellent biocompatibility. Therefore, we hypothesized that coating Ca 2+ -siRNA with BSA helps buffer Ca 2+ oxicity in vivo.

international journal of nanomedicine

&lt;p&gt;Calcium-siRNA Nanocomplexes Optimized by Bovine Serum Albumin Coating Can Achieve Convenient and Efficient siRNA Delivery for Periodontitis Therapy&lt;/p&gt;