Open Access<p>Linalool-Loaded Glutathione-Modified Gold Nanoparticles Conjugated with CALNN Peptide as Apoptosis Inducer and NF-κB Translocation Inhibitor in SKOV-3 Cell Line</p>
Author(s) -
Majid S. Jabir,
Usama I. Sahib,
Zainab J. Taqi,
Ali A. Taha,
Ghassan M. Sulaiman,
Salim Albukhaty,
Ahmed Majeed Al-Shammari,
Mona S. Alwahibi,
Dina A. Soliman,
Yaser Hassan Dewir,
Humaira Rizwana
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s276714
Subject(s) - linalool , apoptosis , cytotoxicity , chemistry , cytotoxic t cell , peptide , glutathione , pharmacology , biochemistry , in vitro , biology , chromatography , essential oil , enzyme
Linalool is a monoterpene compound with various potential therapeutic applications in several medical fields. Previous studies have indicated the activity of linalool against cell lines; however, its high level of toxicity restricts its use. The aim of this study was to design and manufacture compounds with a novel structure that can be used for loading linalool, to reduce its toxicity and improve its reachable ability.