Open AccessA GSH-Responsive Nanoprodrug System Based on Self-Assembly of Lactose Modified Camptothecin for Targeted Drug Delivery and Combination Chemotherapy
Author(s) -
Chenxi Hou,
Ning Ma,
Ziyan Shen,
Guanyu Chi,
Shuang Chao,
Yuxin Pei,
Lan Chen,
Yuchao Lu,
Zhichao Pei
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s276470
Subject(s) - camptothecin , doxorubicin , prodrug , pharmacology , chemistry , glutathione , drug delivery , doxorubicin hydrochloride , drug , chemotherapy , biochemistry , medicine , enzyme , organic chemistry
Conventional chemotherapy using small molecular antitumor drugs suffers from several limitations, for instance poor water solubility, high toxicity, and lack of specificity. However, prodrugs constructed by covalent modification of anticancer drugs can overcome these limitations, which are able to release its active form after entering the tumor tissues by specific stimulus response.