Open Access<p>Both Intracranial and Intravenous Administration of Functionalized Carbon Nanotubes Protect Dopaminergic Neuronal Death from 6-Hydroxydopamine</p>
Author(s) -
OkHyeon Kim,
Jun Hyung Park,
Jong In Son,
Kyung-Yong Kim,
Hyun Jung Lee
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s276380
Subject(s) - hydroxydopamine , dopaminergic , dopamine , pharmacology , carbon nanotube , medicine , oxidopamine , neuroscience , materials science , nanotechnology , biology , substantia nigra
Although single-walled nanotubes (SWNTs) with functional groups have been suggested as a potential nanomedicine to treat neuronal disorders, effective routes to administer SWNTs have not been compared thus far. The blood-brain barrier is a considerable challenge for the development of brain-targeting drugs, and therefore functionalized SWNT routes of administration have been needed for testing Parkinson's disease (PD) treatment. Here, effective administration routes of functionalized SWNTs were evaluated in PD mouse model.