Open AccessFormulation and Characterization of Phytostanol Ester Solid Lipid Nanoparticles for the Management of Hypercholesterolemia: An ex vivo Study
Author(s) -
Sony Chandi Shrestha,
Kebreab Ghebremeskel,
Kenneth White,
Caterina Minelli,
Ihab Tewfik,
Panna Thapa,
Sundus Tewfik
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s276301
Subject(s) - solid lipid nanoparticle , dispersity , bioavailability , nanoparticle , drug delivery , ex vivo , materials science , excipient , nanocarriers , particle size , in vivo , zeta potential , drug carrier , chemistry , nanotechnology , chromatography , pharmacology , organic chemistry , biochemistry , in vitro , medicine , microbiology and biotechnology , biology
Phytostanols are naturally occurring compounds that reduce blood cholesterol levels significantly. However, their aqueous insolubility poses formulation challenges.