Open AccessFacilitated and Controlled Strontium Ranelate Delivery Using GCS-HA Nanocarriers Embedded into PEGDA Coupled with Decortication Driven Spinal Regeneration
Author(s) -
Chih Wei Chiang,
Chih-Hwa Chen,
Yankuba B. Manga,
Shao Chan Huang,
Kun-Mao Chao,
Pei Ru Jheng,
PeiChun Wong,
Batzaya Nyambat,
Mantosh Kumar Satapathy,
Er Yuan Chuang
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s274461
Subject(s) - materials science , biomedical engineering , ethylene glycol , hyaluronic acid , biocompatibility , nanocarriers , in vivo , nanomedicine , strontium ranelate , decortication , drug delivery , pharmacology , nanotechnology , chemistry , medicine , nanoparticle , osteoporosis , surgery , pathology , organic chemistry , metallurgy , anatomy , microbiology and biotechnology , biology
Strontium ranelate (SrR) is an oral pharmaceutical agent for osteoporosis. In recent years, numerous unwanted side effects of oral SrR have been revealed. Therefore, its clinical administration and applications are limited. Hereby, this study aims to develop, formulate, and characterize an effective SrR carrier system for spinal bone regeneration.