Open Access<p>Quality by Design Approach for Preparation of Zolmitriptan/Chitosan Nanostructured Lipid Carrier Particles – Formulation and Pharmacodynamic Assessment</p>
Author(s) -
Randa Hanie Awadeen,
Mariza Fouad Boughdady,
Mahasen Mohamed Meshali
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s274352
Subject(s) - guar gum , sonication , chitosan , materials science , particle size , bioavailability , zolmitriptan , factorial experiment , pharmacodynamics , zeta potential , gelatin , pectin , nanoparticle , chromatography , chemistry , chemical engineering , pharmacology , pharmacokinetics , nanotechnology , biochemistry , medicine , mathematics , agonist , statistics , receptor , sumatriptan , engineering
Zolmitriptan (ZT) is a selective serotonin agonist that is used for the treatment of migraine. It belongs to BCS class III with high solubility and low permeability. Besides, the drug is subjected to pre-systemic metabolism. Accordingly, new Zolmitriptan/chitosan nanostructured lipid carriers (ZT/CT NLCs) coated with Tween 80 (stealthy layer) have been developed to overcome such demerits.