Open Access<p>Neuroprotective Effects of Curcumin-Loaded Emulsomes in a Laser Axotomy-Induced CNS Injury Model</p>
Author(s) -
Elif Nur Yılmaz,
Sadık Bay,
Gürkan Öztürk,
Mehmet Hikmet Üçışık
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s272931
Subject(s) - neuroprotection , curcumin , axotomy , neuroregeneration , ex vivo , pharmacology , neun , medicine , hippocampal formation , in vivo , pathology , biology , endocrinology , immunohistochemistry , central nervous system , microbiology and biotechnology
Curcumin, a polyphenol isolated from the rhizomes of turmeric, holds great potential as a neuroprotective agent in addition to its anti-inflammatory and antioxidant characteristics. The poor bioavailability and low stability of curcumin are the greatest barriers to its clinical use. This study aims to investigate the neuroprotective effect of curcumin on axonal injury, by delivering the lipophilic polyphenol to a primary hippocampal neuron culture by means of a lipid-based drug delivery system, named emulsomes.