Open Access
<p>Biomimetic Synthesis and Evaluation of Interconnected Bimodal Mesostructured MSF@Poly(Ethyleneimine)s for Improved Drug Loading and Oral Adsorption of the Poorly Water-Soluble Drug, Ibuprofen</p>
Author(s) -
Xin Wei,
Yumei Wang,
Xianmou Guo,
Kaijun Gou,
Jing Li,
Sanming Li,
Lin Zhao,
Heran Li
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s272796
Subject(s) - materials science , wetting , adsorption , bioavailability , simulated body fluid , chemical engineering , dissolution , ibuprofen , drug carrier , desorption , drug delivery , nuclear chemistry , chemistry , nanotechnology , scanning electron microscope , organic chemistry , pharmacology , composite material , medicine , engineering
The aim of this study was to improve the oral bioavailability and anti-inflammatory activity of the poorly soluble drug ibuprofen (IBU) by employing a new kind of poly(ethyleneimine)s (PEIs)-based mesocellular siliceous foam (MSF) called B-BMSF@PEI as drug carrier.