Open Access<p>PLGA Nanoparticle Platform for Trans-Ocular Barrier to Enhance Drug Delivery: A Comparative Study Based on the Application of Oligosaccharides in the Outer Membrane of Carriers</p>
Author(s) -
Ge Jiang,
Huanhuan Jia,
Jindi Qiu,
Zhenjie Mo,
Yifeng Wen,
Yan Zhang,
Yuqin Wen,
Qiuling Xie,
Junfeng Ban,
Zhufen Lu,
Yanzhong Chen,
Hao Wu,
Qingchun Ni,
Fohua Chen,
Jiashu Lu,
Zhijiong Wang,
Haoting Li,
Junming Chen
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s272750
Subject(s) - plga , chemistry , chitosan , permeation , nanoparticle , in vivo , pharmacokinetics , drug delivery , drug carrier , membrane emulsification , pharmacology , biophysics , emulsion , materials science , membrane , nanotechnology , biochemistry , organic chemistry , medicine , microbiology and biotechnology , biology
The trans-ocular barrier is a key factor limiting the therapeutic efficacy of triamcinolone acetonide. We developed a poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) surface modified respectively with 2-hydroxypropyl-β-cyclodextrin (2-HP-β-CD), chitosan oligosaccharide and trehalose. Determination of the drug/nanoparticles interactions, characterization of the nanoparticles, in vivo ocular compatibility tests, comparisons of their corneal permeability and their pharmacokinetics in aqueous humor were carried out.