Open Access<p>Antibacterial Activity of Chitosan Nanoparticles Against Pathogenic N. gonorrhoea</p>
Author(s) -
Fulwah Yahya Alqahtani,
Fadilah Sfouq Aleanizy,
Eram El Tahir,
Hiba Alhabib,
Raghad Alsaif,
Gamal A. Shazly,
Hajar AlQahtani,
Ibrahim A. Alsarra,
Jafar Mahdavi
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s272736
Subject(s) - chitosan , zeta potential , minimum bactericidal concentration , antibacterial activity , minimum inhibitory concentration , antimicrobial , neisseria gonorrhoeae , hela , cytotoxicity , dispersity , microbiology and biotechnology , antibiotics , chemistry , particle size , nuclear chemistry , nanoparticle , bacteria , nanotechnology , materials science , in vitro , biology , biochemistry , organic chemistry , genetics
The emergence of Neisseria gonorrhoeae strains that are resistant to the most commonly used antibiotics represents a great concern for global public health. This challenges the effectiveness of clinical treatment regimens and demands the development of alternative antigonococcal agent. In this regard, chitosan nanoparticles (CNPs) are known to have antimicrobial activity against a wide range of pathogens. Thus, they have become a potential candidate for combatting this era of multi-drug resistance. This study aims to formulate CNPs, characterize their physicochemical properties, and examine their antimicrobial activity against gonococcus.