Open Access<p>In vivo Targeting of Liver Cancer with Tissue- and Nuclei-Specific Mesoporous Silica Nanoparticle-Based Nanocarriers in mice</p>
Author(s) -
Ziqiang Ding,
Dujin Wang,
Wei Shi,
Xiaomei Yang,
Siliang Duan,
Fengzhen Mo,
Xiaoqiong Hou,
Aiqun Liu,
Xiaoling Lü
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s272495
Subject(s) - in vivo , nanocarriers , doxorubicin , cytotoxicity , liver cancer , cancer cell , drug delivery , in vitro , chemistry , mesoporous silica , cancer , materials science , cancer research , pharmacology , nanotechnology , biology , biochemistry , chemotherapy , mesoporous material , genetics , microbiology and biotechnology , catalysis
Cancer tissue-specific and nuclei-targeted drug delivery is ideal for the delivery of chemotherapy. However, it has only been achieved in in vitro studies mainly due to low efficiency in vivo. In this study, we aimed to establish an efficient dual-targeted system that targets liver cancer tissue as well as the nuclei of cancer cells in vivo.