Open Access<p>In vitro and in vivo Evaluation of Succinic Acid-Substituted Mesoporous Silica for Ammonia Adsorption: Potential Application in the Management of Hepatic Encephalopathy</p>
Author(s) -
Hamidreza Mohammadi,
Reza Heidari,
Seyyed Vahid Niknezhad,
Akram Jamshidzadeh,
Fatemeh Farjadian
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s271883
Subject(s) - hyperammonemia , hepatic encephalopathy , nuclear chemistry , in vivo , zeta potential , chemistry , succinic anhydride , urea cycle , mesoporous material , succinic acid , pharmacology , materials science , medicine , biochemistry , nanoparticle , organic chemistry , nanotechnology , biology , arginine , cirrhosis , microbiology and biotechnology , amino acid , catalysis
Hepatic encephalopathy (HE) is a critical situation in which liver failure affects brain function. HE could result in a state of coma and death. The liver is the main organ for ammonium ion (NH 4 + ) metabolism. Hence, acute and/or chronic liver failure could lead to hyperammonemia. NH 4 + is the most suspected neurotoxic agent in HE. Thus, finding new therapeutic options to decrease plasma and brain NH 4 + levels has a significant clinical value. Mesoporous silica (MS) particles have revolutionized many aspects of pharmaceutical sciences, including drug delivery systems. Moreover, recently, MS has been applied as agents for the detoxification of chemicals (eg, drugs and poisons).