Open Access<p>Her2-Targeted Multifunctional Nano-Theranostic Platform Mediates Tumor Microenvironment Remodeling and Immune Activation for Breast Cancer Treatment</p>
Author(s) -
Dongdong Zheng,
Caifeng Wan,
Hong Yang,
Li Xu,
Quan Dong,
Chengrun Du,
Jing Du,
Fenghua Li
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s271213
Subject(s) - photothermal therapy , tumor microenvironment , cancer research , breast cancer , materials science , doxorubicin , cancer , cancer cell , drug delivery , photothermal effect , chemistry , nanotechnology , medicine , chemotherapy , tumor cells
The treatment of breast cancer is often ineffective due to the protection of the tumor microenvironment and the low immunogenicity of tumor cells, leading to a poor therapeutic effect. In this study, we designed a nano-theranostic platform for these obstacles: a photothermal effect mediated by a gold shell could remodel the tumor microenvironment by decreasing cancer-associated fibroblasts (CAFs) and promote the release of doxorubicin (DOX) from nanoparticles. In addition, it could realize photoacoustic (PA)/MRI dual-model imaging for diagnose breast cancer and targeted identification of Her2-positive breast cancer.