Open AccessDelivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer
Author(s) -
Yiqing Chen,
Wenting Zhu,
Cai-Yan Lin,
Zhongwen Yuan,
Zhenhua Li,
Pengke Yan
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s270939
Subject(s) - liposome , in vivo , pi3k/akt/mtor pathway , pharmacology , mtt assay , biodistribution , cancer research , flow cytometry , apoptosis , chemistry , medicine , biology , immunology , biochemistry , microbiology and biotechnology
Rapamycin is a promising agent for treating tumors, but clinical applications of rapamycin are limited due to its poor water solubility and low bioavailability. This paper constructs a liposome delivery system for rapamycin to improve the effect in treating colorectal cancer.