Open Access<p>Zein/Phospholipid Composite Nanoparticles for Successful Delivery of Gallic Acid into aHSCs: Influence of Size, Surface Charge, and Vitamin A Coupling</p>
Author(s) -
Shaimaa Ali Ali Radwan,
Walaa H. El-Maadawy,
Carol Yousry,
Aliaa Nabil ElMeshad,
Raguia Aly Shoukri
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s270242
Subject(s) - zeta potential , bioavailability , materials science , in vivo , gallic acid , surface charge , nanoparticle , biodistribution , phospholipid , biophysics , hepatic stellate cell , in vitro , nanotechnology , pharmacology , chemistry , biochemistry , antioxidant , medicine , membrane , biology , pathology , microbiology and biotechnology
Zein/phospholipid composite nanoparticles (CNPs) were developed as a delivery platform for gallic acid (GA), a polyphenolic compound with reported preclinical antifibrotic activities. However, the therapeutic applicability of GA is hampered owing to its low bioavailability and rapid clearance. Accordingly, we developed GA-loaded CNPs. The effect of their size, surface charge and targeting strategies was investigated and optimized, with the aim of enhancing their ability to deliver GA to the activated hepatic stellate cells (aHSCs) in order to suppress hepatic fibrosis progression.