Open Access<p>Synergetic Influence of Bismuth Oxide Nanoparticles, Cisplatin and Baicalein-Rich Fraction on Reactive Oxygen Species Generation and Radiosensitization Effects for Clinical Radiotherapy Beams</p>
Author(s) -
Noor Nabilah Talik Sisin,
Khairunisak Abdul Razak,
Safri Zainal Abidin,
Nor Fazila Che Mat,
Reduan Abdullah,
Raizulnasuha Ab Rashid,
Muhammad Afiq Khairil Anuar,
Wan Nordiana Rahman
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s269214
Subject(s) - reactive oxygen species , radiation therapy , irradiation , radiosensitizer , materials science , brachytherapy , cancer research , bismuth , cisplatin , chemistry , nuclear medicine , medicine , chemotherapy , biochemistry , physics , nuclear physics , metallurgy
This study aimed to quantify synergetic effects induced by bismuth oxide nanoparticles (BiONPs), cisplatin (Cis) and baicalein-rich fraction (BRF) natural-based agent on the reactive oxygen species (ROS) generation and radiosensitization effects under irradiation of clinical radiotherapy beams of photon, electron and HDR-brachytherapy. The combined therapeutic responses of each compound and clinical radiotherapy beam were evaluated on breast cancer and normal fibroblast cell line.