Open Access<p>Primary Amine Modified Gold Nanodots Regulate Macrophage Function and Antioxidant Response: Potential Therapeutics Targeting of Nrf2</p>
Author(s) -
Yueh Hsia Luo,
Hsien Jen Cheng,
Feng Yuan Tsai,
TsuiChun Tsou,
Shu Lin,
Pinpin Lin
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s268203
Subject(s) - antioxidant , macrophage , thp1 cell line , heme oxygenase , inflammation , chemistry , microbiology and biotechnology , cell culture , biochemistry , biology , in vitro , heme , immunology , enzyme , genetics
Gold nanoparticles with high biocompatibility and immunomodulatory properties have potential applications in the development of new diagnostic and therapeutic strategies for nanomedicine. Nanoparticles targeting macrophages can manipulate or control immunological diseases. This study assessed the activity of dendrimer-encapsulated gold nanodots (AuNDs) with three surface modifications [ie, outfacing groups with primary amine (AuNDs-NH2), hydroxyl (AuNDs-OH), and quaternary ammonium ions (AuNDs-CH3)] regulated macrophage function and antioxidant response through Nrf2-dependent pathway.