Open Access<p>Vertical Guided Bone Regeneration in the Rabbit Calvarium Using Porous Nanohydroxyapatite Block Grafts Coated with rhVEGF<sub>165</sub> and Cortical Perforation</p>
Author(s) -
Weizhen Liu,
Bing Du,
Siyi Tan,
Qin Wang,
Yang Li,
Lei Zhou
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s268182
Subject(s) - perforation , cortical bone , medicine , x ray microtomography , anatomy , nuclear medicine , materials science , composite material , radiology , punching
Vertical bone augmentation without osseous walls to support the stability of clots and bone grafts remains a challenge in dental implantology. The objectives of this study were to confirm that cortical perforation of the recipient bed is necessary and to evaluate whether nanohydroxyapatite (nHA) block grafts coated with recombinant human vascular endothelial growth factor 165 (rhVEGF 165 ) and cortical perforation can improve vertical bone regeneration.