Open Access<p>Design and Fabrication of Dual Redox Responsive Nanoparticles with Diselenide Linkage Combined Photodynamically to Effectively Enhance Gene Expression</p>
Author(s) -
Yan Fang,
Xiaojie Lin,
Xuechao Jin,
Dongjuan Yang,
Shan Gao,
Kai Shi,
Mingshi Yang
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s266514
Subject(s) - diselenide , singlet oxygen , transfection , gene delivery , cytotoxicity , nanoparticle , biophysics , redox , materials science , chemistry , in vitro , nanotechnology , selenium , oxygen , biochemistry , gene , biology , organic chemistry
PEI is currently the most used non-viral gene carrier and the transfection efficiency is closely related to the molecular weight; however, the prominent problem is that the cytotoxicity increased with the molecular weight.