Open AccessCancer Therapy with Nanoparticle-Medicated Intracellular Expression of Peptide CRM1-Inhibitor
Author(s) -
Sui Min,
Meimei Xiong,
Yuling Li,
Qiao Zhou,
Xiaofei Shen,
Da Jia,
Maling Gou,
Qingxiang Sun
Publication year - 2021
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s266398
Subject(s) - nuclear export signal , peptide , in vivo , cancer cell , intracellular , cancer research , in vitro , chemistry , pharmacology , cancer , biochemistry , biology , cell nucleus , gene , genetics
Peptides can be rationally designed as non-covalent inhibitors for molecularly targeted therapy. However, it remains challenging to efficiently deliver the peptides into the targeted cells, which often severely affects their therapeutic efficiency.