Open Access<p>Up-Conversion Luminescent Nanoparticles for Molecular Imaging, Cancer Diagnosis and Treatment</p>
Author(s) -
Shuihong Li,
Xiaodan Wei,
Sisi Li,
Chongyu Zhu,
Chunhui Wu
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s266006
Subject(s) - cancer , materials science , cancer imaging , nanoparticle , luminescence , cancer research , molecular imaging , nanotechnology , medicine , optoelectronics , biology , in vivo , microbiology and biotechnology
In the past few years, we have witnessed great development and application potential of various up-conversion luminescent nanoparticles (UCNPs) in the nanomedicine field. Based on the unique luminescent mechanism of UCNPs and the distinguishable features of cancer biomarkers and the microenvironment, an increasing number of smart UCNPs nanoprobes have been designed and widely applied to molecular imaging, cancer diagnosis, and treatment. Considerable technological success has been achieved, but the main obstacles to oncology nanomedicine is becoming an incomplete understanding of nano-bio interactions, the challenges regarding chemistry manufacturing and controls required for clinical translation and so on. This review highlights the progress of the design principles, synthesis and surface functionalization preparation, underlying applications and challenges of UCNPs-based probes for cancer bioimaging, diagnosis and treatment that capitalize on our growing understanding of tumor biology and smart nano-devices for accelerating the commercialization of UCNPs.