Open Access<p>Polyethylene Glycol-Coated Graphene Oxide Loaded with Erlotinib as an Effective Therapeutic Agent for Treating Nasopharyngeal Cancer Cells</p>
Author(s) -
MingYing Lan,
YuSheng Hsu,
MingChin Lan,
JyhPing Chen,
YuJen Lu
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s265437
Subject(s) - erlotinib , nasopharyngeal carcinoma , cancer research , polyethylene glycol , pharmacology , peg ratio , viability assay , medicine , cancer , drug , chemistry , radiation therapy , cell , epidermal growth factor receptor , biochemistry , finance , economics
Nasopharyngeal carcinoma (NPC) is a common cancer in southern China and Taiwan, and radiation therapy combined with or without chemotherapy is its mainstay treatment. Although it is highly sensitive to radiotherapy, local recurrence and distant metastasis remain difficult unsolved problems. In recent years, graphene oxide (GO) has been found to be a promising novel anticancer drug carrier. Here, we present our designed functionalized GO, polyethylene glycol-coated GO (GO-PEG), as a drug carrier, which was loaded with erlotinib and showed promising anticancer effects on NPC cells.