Open Access<p>Anticancer Activity of Thymoquinone Cubic Phase Nanoparticles Against Human Breast Cancer: Formulation, Cytotoxicity and Subcellular Localization</p>
Author(s) -
Mohammed M. Mehanna,
Rana Sarieddine,
Jana K. Alwattar,
Racha Chouaib,
Hala GaliMuhtasib
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s263797
Subject(s) - thymoquinone , bioavailability , apoptosis , cytotoxicity , breast cancer , pharmacology , chemistry , cancer cell , zeta potential , in vitro , viability assay , cancer research , cancer , medicine , materials science , nanoparticle , nanotechnology , biochemistry , antioxidant
Triple negative breast cancer is an aggressive disorder which accounts for at least 15% of breast cancer diagnosis and a high percentage of breast cancer morbidity, hence intensive research efforts are focused on the development of effective therapies to overcome the disease. Thymoquinone (TQ), the bioactive constituent of Nigella sativa , exhibits anticancer activity, yet its translation to the clinic is hindered by its poor bioavailability and lack of quantification method in blood and tissues. To overcome these limitations, cubosomes were utilized for the encapsulation and delivery of this anticancer molecule.