
<p>Bone-Targeted Extracellular Vesicles from Mesenchymal Stem Cells for Osteoporosis Therapy</p>
Author(s) -
Yayu Wang,
Jie Yao,
Lizhao Cai,
Tong Liu,
Xiaogang Wang,
Ye Zhang,
Zhen Zhou,
Tingwei Li,
Minyi Liu,
Renfa Lai,
Xiangning Liu
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s263756
Subject(s) - mesenchymal stem cell , extracellular vesicles , osteoporosis , stem cell , medicine , vesicle , cancer research , extracellular , microbiology and biotechnology , chemistry , pathology , biology , biochemistry , membrane
Current drugs used for osteoporosis therapy show strong adverse effects. Stem cell-derived extracellular vesicles (EVs) provide another choice for osteoporosis therapy. Mouse mesenchymal stem cells (mMSCs)-derived EVs promote bone regeneration; however, their clinical application is limited due to non-specific tissue targeting. Alendronate specifically targets bone tissue via hydroxyapatite. Therefore, EVs were combined with alendronate to generate Ale-EVs by "click chemistry" to facilitate EVs targeting bone via alendronate/hydroxyapatite binding.