Open Access<p><sup>89</sup>Zr-Labeled Multifunctional Liposomes Conjugate Chitosan for PET-Trackable Triple-Negative Breast Cancer Stem Cell Targeted Therapy</p>
Author(s) -
Rui Yang,
Mengji Lu,
Ming Liu,
Yu Chen,
Kai Chen,
Jie Zhou,
ShiWen Jiang,
Zhenyu Lin,
Daozhen Chen
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s262786
Subject(s) - triple negative breast cancer , cd44 , in vivo , cancer stem cell , cancer research , targeted therapy , biodistribution , chemistry , stem cell , breast cancer , cancer , in vitro , biology , medicine , biochemistry , microbiology and biotechnology
Therapy for triple-negative breast cancer (TNBC) is a global problem due to lack of specific targets for treatment selection. Cancer stem cells (CSCs) are responsible for tumor formation and recurrence but also offer a promising target for TNBC-targeted therapy. Here, zirconium-89 ( 89 Zr)-labelled multifunctional liposomes (MLPs) surface-decorated with chitosan (CS) were fabricated to specifically target and trace cluster of differentiation 44 + (CD44 + ) TNBC CSCs specifically.