Open Access<p>Pharmacokinetics and Biodistribution of Thymoquinone-loaded Nanostructured Lipid Carrier After Oral and Intravenous Administration into Rats</p>
Author(s) -
Fatin Hannani Zakarial Ansar,
Saiful Yazan Latifah,
Wan Hamirul Bahrin Wan Kamal,
Khei Choong Khong,
Y. C. Ng,
Jia Ning Foong,
Banulata Gopalsamy,
Wei Keat Ng,
Chee Wun How,
Yong Sze Ong,
Rasedee Abdullah,
Mohd Yusmaidie Aziz
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s262395
Subject(s) - thymoquinone , bioavailability , biodistribution , pharmacokinetics , pharmacology , oral administration , chemistry , absorption (acoustics) , medicine , antioxidant , materials science , biochemistry , in vitro , composite material
Thymoquinone (TQ), an active compound isolated from Nigella sativa , has been proven to exhibit various biological properties such as antioxidant. Although oral delivery of TQ is valuable, it is limited by poor oral bioavailability and low solubility. Recently, TQ-loaded nanostructured lipid carrier (TQ-NLC) was formulated with the aim of overcoming the limitations. TQ-NLC was successfully synthesized by the high-pressure homogenization method with remarkable physiochemical properties whereby the particle size is less than 100 nm, improved encapsulation efficiency and is stable up to 24 months of storage. Nevertheless, the pharmacokinetics and biodistribution of TQ-NLC have not been studied. This study determined the bioavailability of oral and intravenous administration of thymoquinone-loaded nanostructured lipid carrier (TQ-NLC) in rats and its distribution to organs.