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In a previous study, we demonstrated that the combination of fenretinide with lenalidomide, administered by a novel nanomicellar formulation (FLM), provided a strong antitumor effect in a neuroblastoma TrkB-expressing tumor. In this study, we tested the nanomicellar combination in an MYCN amplified neuroblastoma xenograft to assess its efficacy in different tumor genotypes and evaluate the interactions of the nanomicelles with the tumor cells.

international journal of nanomedicine

&lt;p&gt;Nanomicellar Lenalidomide–Fenretinide Combination Suppresses Tumor Growth in an &lt;em&gt;MYCN&lt;/em&gt; Amplified Neuroblastoma Tumor&lt;/p&gt;