Open Access<p>Nanomicellar Lenalidomide–Fenretinide Combination Suppresses Tumor Growth in an <em>MYCN</em> Amplified Neuroblastoma Tumor</p>
Author(s) -
Isabella Orienti,
Giovanna Farruggia,
Ferro Nguyen,
Peng Guan,
Natalia Calonghi,
Venkatadri Kolla,
Michael Chorny,
Garrett M. Brodeur
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s262032
Subject(s) - fenretinide , neuroblastoma , medicine , cancer research , cell culture , retinoid , biology , retinoic acid , genetics
In a previous study, we demonstrated that the combination of fenretinide with lenalidomide, administered by a novel nanomicellar formulation (FLM), provided a strong antitumor effect in a neuroblastoma TrkB-expressing tumor. In this study, we tested the nanomicellar combination in an MYCN amplified neuroblastoma xenograft to assess its efficacy in different tumor genotypes and evaluate the interactions of the nanomicelles with the tumor cells.