Open Access<p>The Impact of Surfactant Composition and Surface Charge of Niosomes on the Oral Absorption of Repaglinide as a BCS II Model Drug</p>
Author(s) -
Morteza Yaghoobian,
Azadeh Haeri,
Noushin Bolourchian,
Soraya Shahhosseni,
Simin Dadashzadeh
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s261932
Subject(s) - niosome , bioavailability , pulmonary surfactant , zeta potential , cmax , repaglinide , chromatography , absorption (acoustics) , poloxamer , chemistry , drug delivery , pharmacokinetics , pharmacology , drug , vesicle , materials science , medicine , organic chemistry , membrane , nanotechnology , biochemistry , nanoparticle , diabetes mellitus , polymer , composite material , endocrinology , type 2 diabetes , copolymer
Niosomes, bilayer vesicles formed by the self-assembly of nonionic surfactants, are receiving increasing attention as potential oral drug delivery systems but the impact of niosomal formulation parameters on their oral capability has not been studied systematically. The aim of this study was to investigate the impact of surfactant composition and surface charge of niosomes in enhancing oral bioavailability of repaglinide (REG) as a BCS II model drug.