Open Access<p>Nanosized Cubosomal Thermogelling Dispersion Loaded with Saquinavir Mesylate to Improve Its Bioavailability: Preparation, Optimization, in vitro and in vivo Evaluation</p>
Author(s) -
Khaled M. Hosny
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s261855
Subject(s) - nasal administration , saquinavir , bioavailability , pharmacology , pharmacokinetics , drug delivery , materials science , polyvinyl alcohol , ex vivo , in vivo , chemistry , medicine , nanotechnology , in vitro , immunology , biochemistry , human immunodeficiency virus (hiv) , antiretroviral therapy , microbiology and biotechnology , viral load , biology , composite material
Low bioavailability and poor permeability of the blood-brain barrier are problematic when delivering therapeutic agents and particularly anti-human immunodeficiency virus therapy to the central nervous system. The intranasal route offers an alternative for central nervous system delivery. Cubosomes have been reported as helpful vehicles for intranasal delivery of therapeutics to enable brain targeting.