Open Access<p>Cetuximab-Coated Thermo-Sensitive Liposomes Loaded with Magnetic Nanoparticles and Doxorubicin for Targeted EGFR-Expressing Breast Cancer Combined Therapy</p>
Author(s) -
Buyankhishig Dorjsuren,
Birendra Chaurasiya,
Zixuan Ye,
Yanyan Liu,
Wei Li,
Chaoyang Wang,
Daren Shi,
Colin E. Evans,
Thomas J Webster,
Yan Shen
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s261671
Subject(s) - doxorubicin , cetuximab , in vivo , breast cancer , cancer research , cancer , viability assay , cytotoxicity , liposome , cancer cell , materials science , iron oxide nanoparticles , medicine , chemotherapy , in vitro , pharmacology , chemistry , nanoparticle , colorectal cancer , biology , nanotechnology , biochemistry , microbiology and biotechnology
One major limitation of cancer chemotherapy is a failure to specifically target a tumor, potentially leading to side effects such as systemic cytotoxicity. In this case, we have generated a cancer cell-targeting nanoparticle-liposome drug delivery system that can be activated by near-infrared laser light to enable local photo-thermal therapy and the release of chemotherapeutic agents, which could achieve combined therapeutic efficiency.