Open Access<p>Finite Element Analysis for Predicting Skin Pharmacokinetics of Nano Transdermal Drug Delivery System Based on the Multilayer Geometry Model</p>
Author(s) -
Yongwei Gu,
Qing Gu,
Qing Yang,
Meng Yang,
Shengzhang Wang,
Jiyong Liu
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s261386
Subject(s) - transdermal , stratum corneum , pharmacokinetics , dermis , microdialysis , in vivo , penetration (warfare) , biomedical engineering , materials science , drug delivery , epidermis (zoology) , permeation , pharmacology , chemistry , medicine , nanotechnology , pathology , anatomy , biology , biochemistry , mathematics , microbiology and biotechnology , operations research , membrane
Skin pharmacokinetics is an indispensable indication for studying the drug fate after administration of transdermal drug delivery systems (TDDS). However, the heterogeneity and complex skin structured with stratum corneum, viable epidermis, dermis, and subcutaneous tissue inevitably leads the drug diffusion coefficient ( K p) to vary depending on the skin depth, which seriously limits the development of TDDS pharmacokinetics in full thickness skin.