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Skin pharmacokinetics is an indispensable indication for studying the drug fate after administration of transdermal drug delivery systems (TDDS). However, the heterogeneity and complex skin structured with stratum corneum, viable epidermis, dermis, and subcutaneous tissue inevitably leads the drug diffusion coefficient ( K p) to vary depending on the skin depth, which seriously limits the development of TDDS pharmacokinetics in full thickness skin.

international journal of nanomedicine

&lt;p&gt;Finite Element Analysis for Predicting Skin Pharmacokinetics of Nano Transdermal Drug Delivery System Based on the Multilayer Geometry Model&lt;/p&gt;