Open Access<p>Self-Assembled Lecithin/Chitosan Nanoparticles Based on Phospholipid Complex: A Feasible Strategy to Improve Entrapment Efficiency and Transdermal Delivery of Poorly Lipophilic Drug</p>
Author(s) -
Wu-Jun Dong,
Jun Ye,
Weijue Wang,
Yanfang Yang,
Hongliang Wang,
Tong Sun,
Lili Gao,
Yuling Liu
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s261162
Subject(s) - transdermal , baicalein , chitosan , lecithin , chemistry , permeation , stratum corneum , lipophilicity , ex vivo , drug delivery , drug carrier , phospholipid , chromatography , pharmacology , membrane , organic chemistry , in vitro , biochemistry , medicine , pathology
Lecithin/chitosan nanoparticles have shown great promise in the transdermal delivery of therapeutic agents. Baicalein, a natural bioactive flavonoid, possesses multiple biological activities against dermatosis. However, its topical application is limited due to its inherently poor hydrophilicity and lipophilicity. In this study, the baicalein-phospholipid complex was prepared to enhance the lipophilicity of baicalein and then lecithin/chitosan nanoparticles loaded with the baicalein-phospholipid complex were developed to improve the transdermal retention and permeability of baicalein.