Open Access<p>A Novel Therapeutic siRNA Nanoparticle Designed for Dual-Targeting CD44 and Gli1 of Gastric Cancer Stem Cells</p>
Author(s) -
Hong-Juan Yao,
Li Sun,
Jingcao Li,
Xiaofei Zhou,
Rui Li,
RongGuang Shao,
Yingge Zhang,
Liang Li
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s260163
Subject(s) - cd44 , hyaluronic acid , small interfering rna , cancer research , in vivo , chemistry , gli1 , gene silencing , cancer cell , transfection , cancer , cell , biology , medicine , biochemistry , signal transduction , genetics , microbiology and biotechnology , gene , hedgehog signaling pathway
Gastric cancer stem cells (CSCs) are important for the initiation, growth, recurrence, and metastasis of gastric cancer, due to their chemo-resistance and indefinite proliferation. Herein, to eliminate gastric CSCs, we developed novel CSC-targeting glioma-associated oncogene homolog 1 ( Gli1 ) small interfering RNA (siRNA) nanoparticles that are specifically guided by a di-stearoyl-phosphatidyl-ethanolamine- hyaluronic-acid (DSPE-HA) single-point conjugate, as an intrinsic ligand of the CD44 receptor. We refer to these as targeting Gli1 siRNA nanoparticles.