Open Access<p>A Non-Lipolysis Nanoemulsion Improved Oral Bioavailability by Reducing the First-Pass Metabolism of Raloxifene, and Related Absorption Mechanisms Being Studied</p>
Author(s) -
Jing-Yi Ye,
Zhongyun Chen,
Chuanli Huang,
Bei Huang,
Yurong Zheng,
Yingfeng Zhang,
Banyi Lu,
Lin He,
Chang-Shun Liu,
Xiaoying Long
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s259993
Subject(s) - bioavailability , lipolysis , chemistry , pharmacology , in vivo , absorption (acoustics) , small intestine , pharmacokinetics , biology , biochemistry , adipose tissue , materials science , microbiology and biotechnology , composite material
A non-lipolysis nanoemulsion (NNE) was designed to reduce the first-pass metabolism of raloxifene (RAL) by intestinal UDP-glucuronosyltransferases (UGTs) for increasing the oral absorption of RAL, coupled with in vitro and in vivo studies.