Open Access<p>Preparation, Characterization and in vivo Study of Borneol-Baicalin-Liposomes for Treatment of Cerebral Ischemia-Reperfusion Injury</p>
Author(s) -
Haoyang Zhang,
Songyu Liu,
Jinyan Wan,
Qian Yang,
Xiang Yan,
Li Ni,
Yu Long,
Mingquan Cui,
Zhimin Ci,
Dongming Tang,
Nan Li
Publication year - 2020
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s259938
Subject(s) - baicalin , liposome , pharmacokinetics , borneol , pharmacodynamics , pharmacology , in vivo , phospholipid , medicine , reperfusion injury , ischemia , materials science , chemistry , chromatography , biochemistry , nanotechnology , pathology , high performance liquid chromatography , biology , alternative medicine , microbiology and biotechnology , traditional chinese medicine , membrane
Baicalin (BA) has a good neuroprotective effect, but it is eliminated quickly in the body and does not easily reach the brain. In this experiment, borneol (BO) was used as an auxiliary drug to prepare borneol-baicalin-liposomes (BO-BA-LP) to prolong the efficacy time of BA, synergistically synergize, introduce drugs into the brain, and better exert the therapeutic effect on cerebral ischemia-reperfusion (I/R) injury.